Application

ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.

Biochem/physiol Actions

ICRF-193 helps in the enhancement of cell cycle withoutchromosome segregation. It is considered as an important drug for chemo-differentiation therapy against acute promyelocytic leukemia (APL). ICRF-193 serves as an inducer of differentiation between anticancer drugs.

ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells.^, ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks.

General description

ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavablecomplex.

Packaging

1, 5 mg in glass bottle

assay	≥95%
biological source	synthetic (organic)
form	solid, powder or flakes
InChI key	OBYGAPWKTPDTAS-OCAPTIKFSA-N
InChI	1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+
Quality Level	200
SMILES string	C[C@@H]([C@@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
solubility	DMSO: 4 mg/mL
storage temp.	−20°C

Safety Data Sheet for I4659-1MG

Cas Number	21416-88-6
Hazard Class	6.1
Un Number	2811
Pack Group	III

This product has met the following criteria to qualify for the following awards:

ICRF-193, apoptosis inducer, arabinosidase substrate

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